Editor - Joseph F. John Jr., MD.

This manual has been released by the Academy of Medicine of New Jersey. The University of Medicine and Dentistry of New Jersey. The New Jersey Department of Health and Senior Services.

The physiologist’s view of fatigue.

Fatigue must arise in one or more of the body’s organ systems. The perception of fatigue is a function of the central nervous system, which relies upon incoming information from the neuromuscular system. Hence, a simplistic model would postulate that the perception of fatigue arises from consequences in either the neuromuscular and/or the central nervous system. Perhaps the perception of fatigue is similar to that of hunger: physiological mechanisms in the gut (and elsewhere) contribute to the perception of hunger, but over-riding emotional stress can prevent an individual from perceiving hunger.

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